80 mg are only for use in patients in whom tolerance to an opioid of comparable potency has been established.

Adult patients who are opioid tolerant are those receiving, for one week or longer, at least 60 mg oral morphine per day

25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone per day,

25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equianalgesic dose of another opioid.